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. 2011 Dec 22;7(12):e1002460. doi: 10.1371/journal.ppat.1002460

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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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The unrooted maximum likelihood tree was constructed with the catalytic domain sequences. Different protein kinase groups, AGC (PKA, PKG, PKC, βARK, ribosomal S6 family PKs and their close relatives), CAMK (calmodulin-regulated kinases), CK1 (casein kinase 1 and close relatives), CMGC (CDKs, MAPKs, GSK, and CDK-like kinases), STE (many kinases involved in the MAPK cascades), and Other (with a conserved kinase domain but could not be classified) are labeled with different colors. Fg05135 contains two catalytic domains (a and b).