. Author manuscript; available in PMC: 2011 Dec 23.

Published in final edited form as: J Hum Genet. 2011 Sep 22;56(12):823–827. doi: 10.1038/jhg.2011.106

Table 3.

CRP association with APOE haplotypes

Haplotype	rs429358-rs7412	Freq	Haplo.score		Haplo.glm
Haplotype	rs429358-rs7412	Freq	score	P	β (SE)	P
APOE ε2	T-T	0.018	0.58	0.56	0.018 (0.070)	0.79
APOE ε3	T-C	0.794	1.59	0.11	reference	reference
APOE ε4	C-C	0.099	-2.83	0.0047	-0.210 (0.075)	5.4 × 10^-3

Using the “haplo.score” function implemented in the “haplo.stats” R package, the global P values for association between haplotypes and CRP level were 0.018. The “haplo.glm” function implemented in the “haplo.stats” R package was used to calculate the coefficient β and P value for each haplotype compared with the reference haplotype (APOE ε3). The same covariates used for genotype analysis were applied in haplotype analysis.