. Author manuscript; available in PMC: 2012 Jun 1.

Published in final edited form as: J Antibiot (Tokyo). 2011 Sep 21;64(12):759–762. doi: 10.1038/ja.2011.86

Table 2. Bioactivity of compounds 1a–d and pyrimethamine.

Each compound was tested at least in triplicate. The therapeutic index is calculated by dividing the cytotoxic ED₅₀ by the EC₅₀ against T. gondii. See Figures S1 and S2 for growth inhibition curves.

Compound	T. gondii ED₅₀ (nM)	HFF1 cytotoxicity ED₅₀ (nM)	Therapeutic Index
1a	230 ± 15	5700 ± 800	25
1b	260 ± 15	2400 ± 300	9
1c	420 ± 30	-	-
1d	1200 ± 60	8000 ± 2000	7
Pyrimethamine	820 ± 60	>50000	>60