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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Hepatology. 2011 Nov 30;55(1):267–276. doi: 10.1002/hep.24681

Fig. 3. Effect of JTE-013 on TCA-induced activation of ERK1/2 and AKT in primary rat hepatocytes.

Fig. 3

Cells were pre-incubated with JTE-013 (10 µM) for 30 minutes and then treated with 100 µM TCA for 20 minutes at 37°C. The protein levels of phosphorylated ERK1/2 (p-ERK1/2) and AKT (p-AKT) were determined by Western blot analysis and normalized with total ERK1/2 (T-ERK1/2) and total AKT (T-AKT) as described in Materials and Methods. *p<0.05 compared to vehicle control, #p<0.05 compared to TCA group, n=3.