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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Hepatology. 2011 Nov 30;55(1):267–276. doi: 10.1002/hep.24681

Fig. 6. Activation of the ERK1/2 and AKT pathways in primary mouse hepatocytes prepared from S1P2−/− and control mice.

Fig. 6

Primary mouse hepatocytes were prepared from the S1P2−/− mouse and wild type littermate and treated with TCA (100 µM) for 20 minutes. The protein levels of phosphorylated ERK1/2 (p-ERK1/2) and AKT (p-AKT) were determined by Western blot analysis and normalized with actin as described in Materials and Methods. **p<0.01 compared to wild type treated with TCA, n=3; ##p<0.01 compared to wild type treated with S1P, n=3.