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. Author manuscript; available in PMC: 2012 Dec 23.
Published in final edited form as: Angew Chem Int Ed Engl. 2011 Nov 9;50(52):12534–12537. doi: 10.1002/anie.201105065

Figure 2. Novel inhibitors of STs and FTs identified from high-throughput screening.

Figure 2

a) Potency and selectivity of validated inhibitors was assessed by titration analysis using the fluorescence polarization assay. Results are the average of at least two independent experiments carried out in triplicate with standard deviations less than 10%. b) Structures of validated sialyltransferase and fucosyltransferase hits include a related set of pan sialyltransferase inhibitors, an ST3Gal III specific inhibitor, and a set of FUT6 specific inhibitors with a related pharmacophore.