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. Author manuscript; available in PMC: 2012 Dec 29.
Published in final edited form as: J Phys Chem B. 2011 Nov 15;115(51):15147–15158. doi: 10.1021/jp207876k

Figure 1.

Figure 1

A ribbon diagram of a monomer of human heart lactate dehydrogenase. The donor and acceptor: the nicotinamide ring, and lactate are colored red. The promoting vibration residues, Val31, Gly32, Met33, Leu65, Gln66 (yellow) are compressed towards the active site bringing the NC4 of the nicotinamide ring and substrate carbon closer together while Arg106 (yellow) relaxes away locking the substrate in product formation. These residues span the entire length of the monomer to the edge of the protein.