Table 1.
Association between T cell infiltration and histology
Adenoma (n=24) | Well differentiated adenocarcinoma (n=9) | Moderately differentiated adenocarcinoma (n=69) | Poorly differentiated adenocarcinoma (n=6) | p-value | |
---|---|---|---|---|---|
T cell infiltration in tumor cell nests
| |||||
CD4 (none: mild: mod.: marked) | 10 : 9: 5 : 0 | 3 : 0 : 4 :2 | 40 : 12 : 12 : 5 | 3 : 2 : 0 : 1 | 0.053 |
CD8 (mild: mod.: marked) | 13 : 11 : 0 | 2 : 6 : 1 | 18 : 41 : 10 | 1 : 2 : 3 | 0.013 |
Ratio (CD4=CD8: CD4>CD8: CD4<CD8) | 10 : 1 : 13 | 4 : 2 : 3 | 12 : 6 : 51 | 0 : 1 : 5 | 0.045 |
| |||||
T cell infiltration in tumor stroma
| |||||
CD4 (none: mild) | 24 : 0 | 8 : 1 | 66 : 3 | 6 : 0 | 0.454 |
CD8 (none: mild: mod.: marked) | 14 : 10 : 0 : 0 | 3 : 6 : 0 : 0 | 26 : 32 : 10 : 1 | 0 : 2 : 4 : 0 | 0.004 |
Ratio (CD4=CD8: CD4>CD8: CD4<CD8) | 14 : 0 : 10 | 4 : 0 : 5 | 29 : 0 : 40 | 0 : 0 : 6 | 0.077 |
Mild < 5%, Moderate 5–25%, Marked > 25% of T cell infiltration.