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. 2004 Feb 1;113(3):357–369. doi: 10.1172/JCI19448

Figure 1.

Figure 1

Comparative morphometry in mice aged 4–6 weeks. (a) When compared with WT (left) and Lmna+/– littermates (center), Lmna–/– (right) mice exhibit growth retardation with 50% reduction in body weight. (b) Despite marked differences in body size, longitudinal sections show that heart sizes are similar in WT (left), Lmna+/– (center), and Lmna–/– (right) mice. Lmna–/– hearts show LV and LA dilation with wall thinning. Scale bar: 2.5 mm. (c) The phenotype of severe DCM without compensatory hypertrophy in 4- to 6-week-old Lmna–/– mice is reflected by Northern blot analyses that show appropriate increases in LV expression of ANP and BNP but no induction of β-MHC or α-skeletal actin. +/+, WT; +/–, Lmna+/–; –/–, Lmna–/–.