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. 2004 Feb 1;113(3):370–378. doi: 10.1172/JCI19670

Figure 1.

Figure 1

Nuclear mechanics is impaired in lamin A/C–deficient cells. (a) Nucleus of WT fibroblast before strain (red) and at 22% strain (yellow). Scale bar: 10 μm. (b) Lmna–/– nucleus before strain (red) and at 19% strain (yellow). Scale bar: 10 μm. (c) Nuclear strain as a function of applied membrane strain. Dashed lines represent linear regression of the data for each cell type forced through the origin (Lmna+/+: y = 0.299x, Lmna–/–: y = 0.626x). (d) Maximal normalized nuclear strain was significantly increased in Lmna–/– fibroblasts (0.306 ± 0.029 vs. 0.626 ± 0.039; P < 0.0001, n = 21).