Figure 5.

Felodipine (FD)-induced vasodilation of aorta segments from ApoE^-/- mice exposed by intratracheal instillation to control solution consisting of 90% saline and 10% BAL fluid (black), nTiO₂ (green), fTiO₂ (blue), or pTiO₂ (red). The measurements are performed in A) absence or B) ex vivo presence of the SOD mimic, tempol. The response is expressed as the percent vasodilation of the pre-contraction tension produced by PGF₂α. Each point on the curves represents the cumulative response at each concentration of the vasodilator. Data are expressed as means ± SEM (n = 10-11).