Table 5.
Inflammatory markers measured in mice exposed to nTiO2 (0.5 mg/kg) or control bronchoalveolar lavage (BAL) suspension by intratracheal instillation once a week for four weeks and sacrificed 5 weeks later (n = 10).
| Exposure i.t. instillation | mRNA expression level (Median (quartile 25-75%)) | ||||
|---|---|---|---|---|---|
| Mcp-1 (*10-9) | Mip-2 (*10-9) | Icam-1 (*10-6) | Vcam-1 (*10-6) | Vegf (*10-6) | |
| Control | 141.9 (98.3-166.5) | 43.2 (39.3-53.0) | 21.8 (17.4-39.0) | 0.30 (0.13-0.50) | 0.70 (0.45-1.18) |
| nTiO2 | 265.9 (80.6-359.5) | 53.3 (25.4-140.2) | 38.9 (18.6-56.9) | 0.40 (0.23-0.83) | 0.90 (0.78-1.38) |
Expression of mRNA is normalised to 18S rRNA.