Table 2.
List of the large conformation change proteins
| Protein name | Free | Partner protein name | Complex | RMSD (Å) (overall) | Conformational change region | RMSD (Å) (local) |
|---|---|---|---|---|---|---|
| Staphylococcus A | 1BDD_A | Human Fc fragment | 1FC2_C | 3.07 | 41-45 | 3.05 |
| Ran GTPase | 1QG4_A | RCC1 | 1I2M_A | 2.62 | 73-75, 126-130, 137-140 | 3.74 |
| 14-3-3 | 1QJB_AB | Serotonin N-acetylase | 1IB1_AB | 3.34 | 129-140, 201-212 | 8.65 |
| Actin | 1IJJ_B | Profilin | 2BTF_A | 2.71 | 37-54 | 5.68 |
| Erythropoietin | 1BUY_A | EPO receptor | 1EER_A | 4.08 | 112-130 | 5.46 |
| Fab fragment | 1GIG_LH | Flu virus hemagglutinin | 2VIS_AB | 4.97 | 105-114 | 3.85 |
| 96-104, 119-124 | ||||||
| TGF-beta | 1TGK_A | TGF-beta receptor | 1KTZ_A | 2.19 | 47-76 | 3.12 |
| Actin | 1IJJ_B | Dnase I | 1ATN_A | 2.71 | 37-54 | 6.14 |
| Coagulation factor Vlla | 1QFK_HL | Soluble tissue factor | 1FAK_HL | 6.23 | 153-165 | 5.16 |
| 35-41 | ||||||
| Ran GTPase | 1QG4_A | Importin-beta | 1IBR_A | 3.90 | 30-34, 39-42 | 8.56 |
| HPr kinase C-ter domain | 1JB1_A | HPr | 1KKL_A | 2.32 | 119-146 | 3.08 |
| HIV1 reverse transcriptase | 1S6P_AB | Fab28 | 2HMI_AB | 3.62 | 69-71, 87-90, 132-134 213-224, 244-252, 291-293 |
3.65 |
| 81-94, 217-231, 352-359 | ||||||
| Ecotin | 1ECZ_AB | D102N trypsin | 1EZU_AB | 2.29 | 84-93 | 1.43 |
| EPO receptor | 1ERN_AB | Erythropoietin | 1EER_BC | 2.72 | 118-123, 125-130 | 3.59 |
| Vitamin D binding | 1KW2_B | Actin | 1KXP_D | 2.12 | 83-114, 247-258, 310-325 | 2.33 |
| Nitrogenase Fe | 2NIP_AB | Nitrogenase Mo-Fe protein | 1N2C_EF | 4.10 | 47-53, 85-88, 124-128 | 1.50 |
| CDK2 kinase | 1B39_A | CDK inhibitor 3 | 1FQ1_B | 3.41 | 55-57, 144-165 | 4.33 |
| Gelsolin | 1D0N_B | Actin | 1H1V_G | 14.06 | 109-120, 210-223, 300-302 | 12.33 |
| Importin-beta | 1F59_A | Ran GTPase | 1IBR_B | 2.95 | 294-310, 331-338, 398-408 | 3.59 |
| Hirustatin | 1BX8_A | Kallikrein | 1HIA_I | 2.05 | 18-20 | 1.98 |
Proteins that undergo large conformational change upon protein-protein interaction are listed in the first column. The following information is given: PDB ID code of the free-state, partner protein name, PDB ID code of the complex-state with a partner protein, RMSD (in Å) between free-state and complex-state, observed conformational change region upon protein-protein interaction, and average RMSD (in Å) of the observed conformational change region. When a protein forms heterodimers, the observed conformational change regions were investigated in each chain.