Table 1.
Histologic scoring system adapted from ISO 10993-6 standard
| Cell type/response | Score
|
||||
|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | |
| Inflammatory cell outcomes | |||||
| Lymphocytes | 0 | Rare—1–5/hpf | 5–10/hpf | Heavy infiltrate | Packed |
| Plasma cells | 0 | Rare—1–5/hpf | 5–10/hpf | Heavy infiltrate | Packed |
| Macrophages | 0 | Rare—1–5/hpf | 5–10/hpf | Heavy infiltrate | Packed |
| Giant cells | 0 | Rare—1–2/hpf | 3–5/hpf | Heavy infiltrate | Packed |
| CCR7+ pro-inflammatory M1 macrophages | 0 | Rare—1–5/hpf | 5–10/hpf | Heavy infiltrate | Packed |
| CD163+ pro-remodeling M2 macrophages | 0 | Rare—1–5/hpf | 5–10/hpf | Heavy infiltrate | Packed |
| Non-inflammatory outcomes | |||||
| Total cellularity | – | < 25% | 26–50% | 51–75% | > 75% |
| Fibroblasts | 0 | Rare—100/hpf | 100–1000/hpf | Heavy infiltrate | Packed |
| CD31+ epithelial cells (neovascularization) | 0 | Minimal capillary proliferation, focal, 1–3 buds | Groups of 4–7 capillaries with supporting fibroblastic structures | Broad band of capillaries with supporting structures | Extensive band of capillaries with supporting fibroblastic structures |
hpf high powered field (×400)