Table 2.
Effect of Acute Olanzapine on Intermediary Metabolites in Fed Rat Gastrocnemiusa
| Metabolite | Control | Olanzapine | P Value |
| nmol/g protein | |||
| Free Co-A | 176 ± 40 | 177 ± 29 | |
| Acetyl-CoA | 525 ± 51 | 491 ± 57 | |
| Malonyl-CoA | 36 ± 6.3 | 16 ± 4 | .017 |
| Citrate | 643 ± 36 | 533 ± 28 | .0024 |
| α-Ketoglutarate | 6622 ± 290 | 4953 ± 278 | .0007 |
| Succinyl-CoA | 47 ± 8.6 | 23 ± 5.1 | .031 |
| Succinate | 573 ± 91 | 762 ± 120 | |
| Fumarate | 2535 ± 129 | 2480 ± 140 | |
| Malate | 4954 ± 133 | 4990 ± 251 | |
| μmol/g protein | |||
| Pyruvate | 29 ± 3 | 32 ± 5 | |
| Lactate | 167 ± 11 | 183 ± 10 | |
| Ala | 15 ± 1 | 16 ± 1 | |
| Arg | 2.9 ± 0.17 | 2.7 ± 0.20 | |
| Asx | 3.25 ± 0.25 | 3.65 ± 0.32 | |
| Cit | 2.05 ± 0.11 | 1.5 ± 0.08 | .004 |
| Gly | 27 ± 2 | 26 ± 1 | |
| Glx | 15.8 ± 0.80 | 13.0 ± 0.65 | .039 |
| His | 2.56 ± 0.11 | 2.69 ± 0.11 | |
| Leu/Ile | 5.2 ± 0.22 | 5.1 ± 0.19 | |
| Met | 0.53 ± 0.021 | 0.53 ± 0.024 | |
| Orn | 0.75 ± 0.040 | 0.53 ± 0.027 | .003 |
| Phe | 1.0 ± 0.05 | 1.2 ± 0.05 | .012 |
| Pro | 4.3 ± 0.2 | 2.9 ± 0.2 | .001 |
| Tyr | 1.6 ± 0.01 | 1.3 ± 0.5 | .024 |
| Val | 1.37 ± 0.057 | 1.58 ± 0.056 | .011 |
Note: All data represent the mean ± SE. P values < .1 are shown.
a
Gastrocnemius samples from figure 4 (n = 8/group) were analyzed for Coenzyme-A (Co-A) species, and other metabolites were measured from a separate cohort of rats not infused with radioactivity (n = 10/group).