Table 2.

The pathways statistically significant in the 3% most increased transcripts in PPARδ agonist-treated cells identified in the multivariate models

P-value	Pathway	Transcripts increased in PPARδ agonist-treated cells mapping to the pathway
6.3e-08	Glucose regulation of insulin secretion	Cycs, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Ndufb9, Atp5a1, Ndufb5, Gpi1, Tpi1, Pgk1, mt-Co2, Sdhb, Sdhd, mt-Atp6, Cox7b, Ndufb2
1.3e-06	Integration of energy metabolism	Cycs, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Ndufb9, Atp5a1, Cpt2, Ndufb5, Gpi1, Tpi1, Pgk1, mt-Co2, Sdhb, Sdhd, mt-Atp6, Cox7b, Ndufb2
1.3e-06	Diabetes pathways	Hspa8, Cycs, Wdr89, Etfa, Mdh2, Aldoa, Dld, Ndufb10, Myo5a, Ndufb9, Atp5a1, Rps21, Rps3a, Sec11c, Ndufb5, Gpi1, Tpi1, Pgk1, Sdhb, mt-Co2, Dnajb9, Sdhd, mt-Atp6, Cox7b, 2900062L11Rik, Ndufb2
8.5e-06	Electron transport chain	Cycs, Ndufb5, Etfa, mt-Co2, Ndufb10, Sdhb, Sdhd, Ndufb9, Cox7b, Ndufb2
7.1e-04	Citric acid cycle (TCA cycle)	Dld, Sdhb, Sdhd, Mdh2
1.4e-03	Mitochondrial fatty acid β-oxidation of saturated and unsaturated fatty acids	Hadhb, Acadl, Acadvl
1.6e-03	Glycolysis	Aldoa, Tpi1, Pgk1, Gpi1
4.5e-03	Metabolism of lipids and lipoproteins	Agpat3, Hadhb, Ppp1cc, Slc27a1, Lass2, Angptl4, Cpt2, Akr1b3, Abcd3, Acadl, Sgpl1, Acaa2, Acadvl, Mod1, Hmgcs2, Adfp
7.8e-03	Formation of acetoacetic acid in synthesis of ketone bodies	Hmgcs2, Acaa2

Transcripts in bold were increased in both PPARδ and PPARγ agonist-treated cells.