Table 3.
Associations of Sleep Disordered Breathing, Nocturnal Hypoxemia and Cognition. Adjusted Means (95% Confidence Interval).
| Trails B Completion Time (seconds) | 3MS Score | DVT Completion Time (seconds) | ||||
|---|---|---|---|---|---|---|
| Minimally | Multivariate | Minimally | Multivariate | Minimally | Multivariate | |
| Predictor | Adjusted* | Adjusted† | Adjusted* | Adjusted† | Adjusted* | Adjusted† |
| Apnea-Hypopnea Index (per hour sleep) | ||||||
| <5 (n = 618) | 109.5 (106.3, 112.9) | 109.4 (106.1, 112.8) | 93.0 (92.6, 93.4) | 93.0 (92.6, 93.4) | 527.9 (516.3, 539.7) | 527.6 (516.1, 539.3) |
| 5 to <15 (n = 1,029) | 110.1 (107.5, 112.7) | 110.3 (107.8, 112.8) | 93.2 (92.9, 93.5) | 93.2 (92.9, 93.5) | 530.4 (521.5, 539.6) | 531.5 (522.7, 540.4) |
| 15 to <30 (n = 759) | 113.1 (110.0, 116.2) | 113.3 (110.4, 116.4) | 93.0 (92.7, 93.4) | 93.1 (92.8, 93.5) | 530.4 (520.0, 541.1) | 532.2 (522.0, 542.7) |
| 30+ (n = 503) | 112.8 (109.1, 116.8) | 111.7 (108.0, 115.5) | 92.9 (92.5, 93.4) | 93.0 (92.6, 93.5) | 534.7 (521.7, 548.1) | 527.4 (514.6, 540.4) |
| P-trend | 0.087 | 0.166 | 0.595 | 0.926 | 0.492 | 0.963 |
| % Sleep Time with SaO2<90% | ||||||
| <1% (n = 1,410) | 110.9 (108.7, 113.2) | 111.4 (109.1, 113.7) | 93.1 (92.8, 93.3) | 93.1 (92.8, 93.3) | 526.7 (519.0, 534.5) | 528.7 (520.9, 536.6) |
| 1 to <3.5% (n =767) | 111.2 (108.3, 114.3) | 111.3 (108.4, 114.3) | 93.1 (92.7, 93.4) | 93.1 (92.7, 93.4) | 529.4 (519.1, 539.9) | 529.9 (519.8, 540.1) |
| 3.5 to <10%(n=374) | 111.0 (106.8, 115.5) | 110.6 (106.4, 114.9) | 93.2 (92.6, 93.7) | 93.2 (92.7, 93.7) | 532.7 (517.8, 548.1) | 530.2 (515.6, 545.3) |
| 10%+ (n = 358) | 112.4 (108.0, 117.0) | 110.2 (105.8, 114.8) | 93.0 (92.5, 93.5) | 93.2 (92.6, 93.7) | 546.9 (531.2, 563.1) | 536.2 (520.6, 552.4) |
| P-trend | 0.640 | 0.643 | 0.901 | 0.635 | 0.037 | 0.475 |
| Any Sleep Time with SaO2<80% | ||||||
| No (n = 2,715) | 111.1 (109.5, 112.7) | 111.1 (109.6, 112.7) | 93.1 (92.9, 93.3) | 93.1 (92.9, 93.3) | 528.5 (523.0, 534.1) | 528.7 (523.3, 534.1) |
| Yes (n = 194) | 113.2 (107.1, 119.6) | 111.3 (105.4, 117.7) | 92.6 (91.9, 93.4) | 92.8 (92.1, 93.5) | 561.2 (539.5, 583.6) | 551.0 (529.8, 573.2) |
| P-value | 0.524 | 0.941 | 0.215 | 0.382 | 0.004 | 0.046 |
*
Adjusted for age, race, and clinic.
†
Adjusted for age, race, clinic, body mass index, instrumental activities of daily living, comorbidities, antidepressant use, benzodiazepine use, Geriatric Depression Scale score, education, alcohol use, smoking, physical activity, and self-reported health status.
DVT=Digit Vigilance Test.