Skip to main content
. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Cancer Res. 2011 Jun 14;71(15):5182–5193. doi: 10.1158/0008-5472.CAN-10-2016

Figure 3.

Figure 3

Synergistic effect of treatment with BA and MIT on inhibition of pancreatic cancer cell migration and invasion. A, FG cells in triplicate were pretreated with BA at concentrations ranging from 2.5, or 5μM, or pretreated with 2.5μM BA, 0.01 μM MIT or both for 24 h, the cultures were wounded by scratching and maintained for additional 24 h. Cell cultures were photographed and cell migration was assessed by measuring gap sizes (inserted number represented percent area of gap ± SD). B, FG cells were treated with BA at concentrations ranging from 2.5, 5, and 10μM or MIT at concentrations ranging from 0.01, 0.05, and 0.10μM for 24 h, or FG cells were treated with 2.5μM BA, 0.01 μM MIT or both for 24 h. Representative tumor cell invaded through Matrigel were photographed, while the numbers of invasive cells that penetrated through Matrigel-coated filter were counted in 15 random fields identified within the lower surface of the filters and expressed as % of control (inserted numbers). Data represents mean ± SD of triplicates. *P<0.05 and #P<0.01 (two-tailed student t test).