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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Drug Deliv Transl Res. 2011 Dec 1;1(6):409–419. doi: 10.1007/s13346-011-0046-y

Figure 3.

Figure 3

Mechanism of neuroprotection treated with SOD-NPs. Animal from the acute study were analyzed for BBB integrity and histological analysis. A) Representative brain showing Evans blue leakage in saline control and SOD-NPs-treated rats at 6 h after reperfusion. More blue color represents breakdown of BBB. B) Representative electron microscopic photomicrographs of penumbral region of brain sections of sham, saline control, and SOD-NPs-treated rats at 6 h after reperfusion. The results show inhibition of apoptosis in SOD-NPs-treated animals whereas saline control shows apoptotic nucleus. Bar = 500 nm. Figure reproduced with permission from Ref [57].