Table 2.
Mean blood pressure, potassium, and electrocardiographic changes from baseline through 48 months by treatment group for C- and H-clinics in MRFIT.
| C-clinics | H-clinics | ||||||
|---|---|---|---|---|---|---|---|
| Variable | SI | UC | SI-UC difference (S.E.) |
SI | UC | SI-UC difference (S.E.) |
P-Value for interaction* |
| Systolic blood pressure (mm Hg) |
−19.7 | −9.4 | −10.4 (0.4) | −18.1 | −9.5 | −8.6 (0.3) | .001 |
| Diastolic blood pressure (mm Hg) |
−11.5 | −5.0 | −6.5 (0.3) | −11.3 | −6.3 | −5.1 (0.2) | .000 |
| Potassium (mmol/L) | −0.42 | −0.08 | −0.33 (0.02) | −0.31 | −0.08 | −0.23 (0.01) | .000 |
| Electrocardiographic Measurement | |||||||
| R amplitude aVL (μV) | −13.3 | 7.1 | −20.4 (4.6) | 20.8 | 32.3 | −11.5 (4.4) | .218 |
| S Amplitude V3 (μV) | −136.1 | −88.7 | −47.4 (8.5) | −138.7 | −114.2 | −24.5 (7.1) | .066 |
| QRS duration (ms) | 0.7 | −0.3 | 1.0 (0.2) | 1.2 | 0.4 | 0.8 (0.2) | .552 |
| Criteria for Electrocardiographic Left Ventricular Hypertrophy | |||||||
| Sokolow-Lyon (μV) | −346.3 | −252.4 | −93.9 (15.1) | −297.1 | −242.2 | −54.9 (12.1) | .049 |
| Cornell voltage (μV) | −149.5 | −81.4 | −68.1 (9.6) | −117.9 | −82.0 | −35.9 (8.0) | .019 |
| Cornell voltage product (μV/ms) |
−11.9 | −7.4 | −4.6 (0.9) | −8.7 | −6.5 | −2.2 (0.8) | .071 |
| Left ventricular mass (gm) |
−8.4 | −4.1 | −4.4 (0.4) | −7.5 | −4.7 | −2.8 (0.3) | .002 |
*
The p-value for interaction assesses whether the SI-UC differences for C- and H- clinics differ significantly from one another.
SI = special intervention; UC = usual care