FIG. 1.

(A) Schematic representation of the biopsy model with a chondral defect, (B) with a subchondral defect, (C) with an osteochondral defect, (D) H&E-stained osteochondral biopsy after 28 days of culture; scale bar indicates 3 mm. Insets: detail images of cartilage and bone, respectively, scale bars indicate 400 μm. (E) Schematic representation of validation settings of the osteochondral biopsy model: (1) osteochondral defect seeded with bovine chondrocytes covered with a ChondroGide membrane and fibrin glue; (2) osteochondral defect with a ChondroGide membrane, preseeded with bovine chondrocytes covered with fibrin glue. H&E, hematoxylin and eosin. Color images available online at www.liebertonline.com/tec