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. Author manuscript; available in PMC: 2011 Dec 29.
Published in final edited form as: IEEE Trans Biomed Eng. 2009 Jul 31;56(12):2782–2795. doi: 10.1109/TBME.2009.2028015

Figure 7.

Figure 7

simulated intracellular activity versus extracellular field activity in pyramidal cells and interneurons during an epileptic spike. The early sharp positive component (“spike”) of the interictal event is caused by the synchronized activity of pyramidal cells at the very onset of the stimulation. Synchronized APs contribute to the LFP. The early “spike” component is followed by a slower negative wave explained by the sustained activity of interneurons. For this slow component, the synaptic activity of both interneurons and pyramidal cells (mixture of both gabaergic and glutamatergic currents) contribute to the LFP.