. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Amino Acids. 2011 Aug 2;42(2-3):495–505. doi: 10.1007/s00726-011-1028-6

Table 5.

Polyamine content in control, CAG-SpdS, CAG-SpmS and CAG-SpdS/CAG-SpmS mice

Tissue	Group	Polyamine content (pmol/mg tissue)			Spm:Spd ratio
Tissue	Group	Putrescine	Spermidine	Spermine	Spm:Spd ratio
Heart	Control	32 ± 5	219 ± 15	383 ± 14	1.8 ± 0.1
	CAG-SpdS	25 ± 1^*	322 ± 28^**	330 ± 24^**	1.0 ± 0.1^**
	CAG-SpmS	46 ± 9^*	128 ± 18^**	477 ± 28^**	3.8 ± 0.6^**
	CAG-SpdS/CAG-SpmS	44 ± 6^*	165 ± 12^**	430 ± 24^**	2.6 ± 0.2^**

Muscle	Control	36 ± 5	172 ± 54	286 ± 89	1.8 ± 0.7
	CAG-SpdS	24 ± 3^**	323 ± 15^**	212 ± 29	0.7 ± 0.1^*
	CAG-SpmS	47 ± 9^*	75 ± 24^**	309 ± 33	4.4 ± 1.4^**
	CAG-SpdS/CAG-SpmS	36 ± 11	151 ± 50	278 ± 68	2.0 ± 0.6

Liver	Control	32 ± 6	879 ± 61	814 ± 62	0.9 ± 0.1
	CAG-SpdS	26 ± 1	1009 ± 142^*	486 ± 71^**	0.5 ± 0.1^**
	CAG-SpmS	58 ± 18^*	527 ± 112^**	1252 ± 140^**	2.4 ± 0.4^**
	CAG-SpdS/CAG-SpmS	58 ± 22^*	539 ± 51^**	1040 ± 79^**	1.9 ± 0.1^**

Kidney	Control	41 ± 5	397 ± 40	821 ± 30	2.1 ± 0.2
	CAG-SpdS	38 ± 9	474 ± 35^*	773 ± 40	1.6 ± 0.1^*
	CAG-SpmS	67 ± 13^**	232 ± 34^**	964 ± 61^**	4.2 ± 1.0^**
	CAG-SpdS/CAG-SpmS	61 ± 13^**	250 ± 22^**	920 ± 81^*	3.7 ± 0.5^**

Brain	Control	21 ± 3	270 ± 71	322 ± 29	1.3 ± 0.3
	CAG-SpdS	25 ± 4	275 ± 51	333 ± 22	1.2 ± 0.3
	CAG-SpmS	29 ± 3^**	208 ± 22	405 ± 58^*	2.0 ± 0.1^**
	CAG-SpdS/CAG-SpmS	35 ± 7^**	206 ± 22^*	398 ± 94	1.9 ± 0.4^**

Polyamine content (mean ± S.D.) was measured in tissues from 5-week-old control (n=6), CAG-SpdS (n=4), CAG-SpmS (n=5) and CAG-SpdS/CAG-SpmS (n=8) mice.

p<0.05,

^**

p<0.005 vs. wild type controls.