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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Nat Neurosci. 2011 Nov 20;15(1):23–25. doi: 10.1038/nn.2962

Figure 1. Orally-administered caffeine potentiates synaptic responses in CA2.

Figure 1

The placement of stimulating and recording electrodes in coronal slices is shown in the schematic diagrams for areas CA2 (a) and CA1 (b). Sample currents evoked by increasing stimulation intensity from single neurons in slices from rats dosed with 20 mg/kg caffeine or vehicle (CA2, c; CA1, d). EPSCs evoked by a range of stimulation intensities in slices following oral administration of caffeine are enhanced in CA2 relative to vehicle (e), but not in CA1 (f). Note: bars indicate mean ± SEM in this and subsequent figures, and experiments were approved by the NIEHS Animal Care and Use Committee. No change in the intrinsic excitability of CA2 neurons was detected at any dose of caffeine (g–i).