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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Biol Psychiatry. 2011 Aug 27;71(3):224–231. doi: 10.1016/j.biopsych.2011.07.009

Figure 3.

Figure 3

Enhancement of cocaine-induced sensitization in Early Life and Lifetime GRov mice. (A) Distance traveled in response to the cocaine challenge was significantly increased at Day 14 relative to Day 1 in all four groups of bigenic mice. ANOVA revealed a significant group × day interaction among No-, Lifetime, and Early Life GRov mice (p < .05). ***p < .001 versus respective group on Day 1. (B) The difference in distance traveled between Day 14 and Day 1. Both Lifetime and Early Life GRov mice showed a greater degree of sensitization using this measure compared to No-GRov mice. GRov, glucocorticoid receptor overexpression in forebrain. *p < .05 and **p < .01 versus No-GRov group. n = 9–16 mice per group.