Table 1.
Alterations in GR Signaling Pathway in DG
| Early Life vs No-GRov | Lifetime vs No-GRov | ||||
|---|---|---|---|---|---|
| Gene | RefSeq ID | FC | p | FC | p |
| CCL2 | NM_011331 | −1.19 | .018 | −1.19 | .011 |
| CCL11 | NM_011330 | −1.26 | .001 | −1.36 | .001 |
| CD3E | NM_007648 | −1.19 | .003 | −1.18 | .001 |
| CSN2 | NM_009972 | −1.19 | .001 | −1.17 | .007 |
| GTF2A2 | NM_001039519 | 1.19 | .031 | 1.17 | .046 |
| GTF2H1* | NM_008186 | −1.24 | .029 | −1.25 | .055 |
| GTF2H5 | NM_181392 | 1.16 | .049 | 1.19 | .016 |
| HSP90AA1* | NM_010480 | 1.40 | .003 | 1.27 | .022 |
| HSP90AB1* | NM_008302 | 1.84 | .002 | 1.60 | .046 |
| HSPA2* | NM_001002012 | 1.67 | .006 | 1.77 | .007 |
| IL2 | NM_008366 | −1.17 | .007 | −1.11 | .011 |
| IL1RN | NM_001039701 | −1.10 | .023 | −1.10 | .015 |
| JAK1* | NM_146145 | 1.16 | .124 | 1.20 | .004 |
| JAK3 | NM_010589 | −1.19 | .004 | −1.21 | .003 |
| KRT35 | NM_016880 | −1.12 | .044 | −1.15 | .011 |
| JUN* | NM_010591 | 1.32 | .110 | 1.72 | .001 |
| MAP2K1* | NM_008927 | 1.25 | .082 | 1.30 | .017 |
| MAP3K7IP1* | NM_025609 | −1.14 | .014 | −1.11 | .057 |
| MAPK1* | NM_001038663 | 1.31 | .096 | 1.22 | .178 |
| MAPK11 | NM_011161 | −1.24 | .001 | −1.20 | .006 |
| MAPK13 | NM_011950 | −1.23 | .028 | −1.23 | .029 |
| MED1 | NM_134027 | 1.27 | .004 | 1.25 | .002 |
| NCOR1 | NM_011308 | 1.38 | .001 | 1.30 | .001 |
| NFKBIA | NM_010907 | 1.24 | .033 | 1.28 | .045 |
| NRAS | NM_010937 | 1.11 | .045 | 1.11 | .040 |
| NRIP1 | NM_173440 | 1.26 | .044 | 1.28 | .012 |
| PCK2 | NM_028994 | −1.27 | .018 | −1.28 | .005 |
| PGR | NM_008829 | −1.30 | .013 | −1.31 | .020 |
| PIK3C2G | NM_011084 | −1.14 | .002 | −1.12 | .004 |
| PIK3R4 | NM_001081309 | 1.38 | .002 | 1.32 | .001 |
| POLR2A* | NM_009089 | −1.35 | .007 | −1.52 | .001 |
| POLR2H | NM_145632 | 1.20 | .047 | 1.33 | .002 |
| POU2F2 | NM_001163554 | −1.40 | .001 | −1.31 | .001 |
| RRAS* | NM_009101 | −1.14 | .043 | −1.18 | .005 |
| SLPI | NM_011414 | −1.17 | .042 | −1.22 | .020 |
| SMARCA2 | NM_011416 | 1.59 | .001 | 1.53 | .004 |
| SRA1 | NM_001164406 | −1.29 | .003 | −1.16 | .042 |
| STAT5A | NM_001164062 | −1.13 | .006 | −1.14 | .015 |
| TAF10* | NM_020024 | −1.44 | .006 | −1.33 | .015 |
| TAF11 | NM_026836 | −1.18 | .035 | −1.14 | .050 |
| TAF7L | NM_001161855 | −1.12 | .033 | −1.13 | .012 |
| TGFB1* | NM_011577 | −1.26 | .012 | −1.20 | .086 |
| TRAF2* | NM_009422 | −1.19 | .048 | −1.22 | .017 |
This list includes genes that are altered in DG and shared by Lifetime and Early Life GRov mice when compared to No-GRov mice. Fold changes (FC) of gene expression represent either Lifetime or Early Life GRov mice compared with No-GRov animals. GR, glucocorticoid receptor; GRov, glucocorticoid receptor overexpression in forebrain; DG, dentate gyrus. Genes with asterisk mark have been confirmed by qRT-PCR. n = 6 mice per group.