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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Nat Neurosci. 2011 Dec 11;15(1):113–122. doi: 10.1038/nn.2993

Figure 7.

Figure 7

Fractional contribution of the AMPAR-, KAR-, and NMDAR-mediated synaptic components to the compound EPSP during the TSt-CSt paired stimulation. (a) Examples of the EPSPs recorded in a LAn neuron in current-clamp mode evoked by paired stimulation of thalamic and cortical inputs with a 15 ms interval under control conditions (1) and in the presence of SYM 2206 (2), NBQX (3), and NBQX + D-AP5 (4). Reponses were evoked once every 20 s. Note significant spatiotemporal summation of EPSPs during the TSt-CSt paired stimulation. (b) Time course of the EPSP depression during application of SYM 2206, NBQX, and NBQX + D-AP5 (indicated by bars above the graph). Peak amplitude of EPSPs was normalized to the baseline EPSP amplitude (n = 6). (c) Examples of isolated (subtracted) AMPAR-, KAR-, and NMDAR-mediated EPSPs from an experiment shown in (a): EPSPAMPAR = EPSPcontrol − EPSPSYM2206; EPSPKAR = EPSPSYM2206 − EPSPNBQX; EPSPNMDAR = EPSPNBQX − EPSPNBQX+D-AP5. (d) Fractional contribution of the AMPAR-, KAR-, and NMDAR-EPSPs in the compound EPSP (based on the peak amplitude measurements) during paired TSt-CSt stimulation (n = 6). Error bars indicate s.e.m.