Table 2.
Within-sib-pair association estimates for quantitative traits related to type 2 diabetes (adjusted for BMI)
| SNP (minor allele) | Gene | β coefficienta (95% CI), p valueb | |||
|---|---|---|---|---|---|
| Fasting glucose (n = 5,056) | Fasting insulin (n = 5,054) | HOMA-IR (n = 5,053) | HOMA-β (n = 5,053) | ||
| rs1799854 (T) | ABCC8 | −0.006 (−0.008, 0.006), 0.86 | 0.002 (−0.05, 0.06), 0.94 | 0.002 (−0.05, 0.05), 0.93 | −0.004 (−0.04, 0.03), 0.83 |
| rs2641348 (G) | ADAM30 | 0.0008 (−0.007, 0.009), 0.85 | −0.08* (−0.15, −0.02), 0.01 | −0.07* (−0.12, −0.005), 0.03 | −0.05* (−0.10, −0.01), 0.01 |
| rs10490072 (C) | BCL11A | 0.001 (−0.01, 0.012), 0.86 | −0.04 (−0.13, 0.05), 0.37 | −0.04 (−0.12, 0.04), 0.36 | −0.03 (−0.09, 0.03), 0.38 |
| rs12779790 (G) | CDC123/CAMK1D | 0.005 (−0.004, 0.01), 0.28 | 0.008 (−0.06, 0.08), 0.82 | 0.007 (−0.06, 0.08), 0.84 | 0.005 (−0.05, 0.06), 0.85 |
| rs10811661 (C) | CDKN2A/B | −0.003 (−0.01, 0.007), 0.58 | −0.08* (−0.15, −0.01), 0.02 | −0.08* (−0.15, −0.01), 0.02 | −0.05* (−0.11, −0.004), 0.03 |
| rs10946398 (C) | CDKAL1 | 0.005 (−0.003, 0.01), 0.23 | 0.02 (−0.04, 0.08), 0.55 | 0.02 (−0.03, 0.08), 0.41 | 0.003 (−0.04, 0.04), 0.89 |
| rs7754840 (C) | CDKAL1 | 0.004 (−0.003, 0.01), 0.24 | 0.01 (−0.04, 0.07), 0.61 | 0.02 (−0.03, 0.08), 0.43 | −0.002 (−0.04, 0.04), 0.91 |
| rs7756992 (G) | CDKAL1 | 0.01* (0.002, 0.02), 0.01 | −0.006 (−0.06, 0.05), 0.84 | 0.001 (−0.05, 0.06), 0.96 | −0.03 (−0.07, 0.01), 0.15 |
| rs932206 (T) | CXCR4 | −0.009* (−0.02, −0.0005), 0.04 | −0.004 (−0.08, 0.07), 0.90 | −0.02 (−0.09, 0.04), 0.49 | 0.04 (−0.01, 0.09), 0.15 |
| rs1153188 (A) | DCD | −0.005 (−0.013, 0.003), 0.22 | −0.04 (−0.10, 0.02), 0.24 | −0.04 (−0.10, 0.02), 0.19 | −0.013 (−0.06, 0.03), 0.57 |
| rs17044137 (A) | FLJ39370 d | 0.003 (−0.007, 0.01), 0.53 | −0.03 (−0.11, 0.05), 0.50 | −0.02 (−0.11, 0.05), 0.53 | −0.02 (−0.08, 0.04), 0.47 |
| rs9939609 (A) | FTO | −0.007 (−0.014, 0.0002), 0.06 | 0.01 (−0.04, 0.07), 0.65 | 0.01 (−0.04, 0.06), 0.65 | 0.03 (−0.008, 0.07), 0.12 |
| rs5015480 (C) | HHEX | −0.004 (−0.01, 0.002), 0.20 | 0.009 (−0.04, 0.06), 0.71 | 0.01 (−0.04, 0.06), 0.63 | 0.03 (−0.008, 0.06), 0.12 |
| rs1111875 (G) | HHEX | 0.003 (−0.003, 0.01), 0.31 | −0.02 (−0.07, 0.03), 0.53 | −0.02 (−0.07, 0.03), 0.48 | −0.03 (−0.06, 0.009), 0.14 |
| rs7923837 (G) | HHEX | 0.004 (−0.003, 0.01), 0.26 | −0.01 (−0.06, 0.04), 0.64 | −0.01 (−0.06, 0.04), 0.63 | −0.03 (−0.06, 0.01), 0.16 |
| rs2268573 (G) | GCK | 0.004 (−0.002, 0.01), 0.23 | 0.03 (−0.02, 0.08), 0.20 | 0.03 (−0.02, 0.08), 0.28 | 0.01 (−0.02, 0.05), 0.55 |
| rs2237892 (T) | KCNQ1 | 0.006 (−0.02, 0.03), 0.70 | −0.04 (−0.26, 0.18), 0.73 | −0.03 (−0.25, 0.18), 0.77 | −0.04 (−0.20, 0.12), 0.61 |
| rs2876711 (C) | KCTD12 | 0.001 (−0.006, 0.008), 0.76 | −0.02 (−0.07, 0.03), 0.47 | −0.01 (−0.07, 0.04), 0.56 | −0.01 (−0.05, 0.02), 0.45 |
| rs1256517 (C) | LOC646279 | 0.007 (−0.003, 0.02), 0.17 | −0.03 (−0.11, 0.04), 0.37 | −0.03 (−0.10, 0.04), 0.45 | −0.04 (−0.10, 0.01), 0.12 |
| rs10823406 (A) | NGN3 | −0.0003 (−0.008, 0.008), 0.99 | −0.02 (−0.08, 0.04), 0.58 | −0.02 (−0.08, 0.04), 0.48 | −0.004 (−0.05, 0.04), 0.86 |
| rs10923931 (T) | NOTCH2 | −0.0001 (−0.008, 0.008), 0.97 | −0.06* (−0.12, −0.001), 0.04 | −0.05 (−0.11, 0.008), 0.09 | −0.04 (−0.08, 0.004), 0.07 |
| rs1801282 (G) | PPARG | −0.005 (−0.02, 0.005), 0.33 | −0.01 (−0.09, 0.06), 0.72 | −0.009 (−0.09, 0.07), 0.81 | 0.01 (−0.05, 0.07), 0.70 |
| rs3856806 (T) | PPARG | −0.005 (−0.01, 0.004), 0.27 | 0.01 (−0.05, 0.08), 0.66 | 0.02 (−0.05, 0.09), 0.57 | 0.03 (−0.02, 0.08), 0.21 |
| rs13266634 (T) | SLC30A8 | −0.005 (−0.01, 0.003), 0.20 | −0.006 (−0.07, 0.06), 0.84 | −0.01 (−0.07, 0.05), 0.70 | 0.007 (−0.04, 0.05), 0.77 |
| rs7578597 (Tc) | THADA | −0.003 (−0.012, 0.006), 0.53 | −0.02 (−0.09, 0.05), 0.57 | −0.015 (−0.08, 0.05), 0.66 | 0.0009 (−0.05, 0.05), 0.97 |
| rs757210 (A) | TCF2 | −0.001 (−0.008, 0.006), 0.78 | 0.05* (−0.001, 0.11), 0.05 | 0.05* (0.003, 0.11), 0.04 | 0.04 (−0.003, 0.08), 0.07 |
| rs7903146 (T) | TCF7L2 | 0.007* (−0.0001, 0.01), 0.05 | 0.009 (−0.05, 0.06), 0.75 | 0.006 (−0.05, 0.06), 0.82 | −0.01 (−0.05, 0.03), 0.58 |
| rs12255372 (T) | TCF7L2 | 0.01* (0.004, 0.02), 0.003 | −0.009 (−0.06, 0.06), 0.98 | −0.009 (−0.06, 0.06), 0.97 | −0.03 (−0.07, 0.01), 0.19 |
| rs7961581 (C) | TSPAN8,LGR5 | −0.0003 (−0.007, 0.007), 0.93 | −0.02 (−0.08, 0.03), 0.39 | −0.02 (−0.07, 0.03), 0.41 | −0.01 (−0.05, 0.02), 0.44 |
| rs9472138 (T) | VEGFA | −0.002 (−0.01, 0.007), 0.68 | −0.03 (−0.10, 0.04), 0.38 | −0.02 (−0.09, 0.05), 0.57 | −0.02 (−0.07, 0.03), 0.44 |
| rs10010131 (A) | WFS1 | 0.001 (−0.007, 0.009), 0.79 | 0.01 (−0.05, 0.07), 0.74 | 0.004 (−0.05, 0.06), 0.88 | 0.004 (−0.04, 0.05), 0.86 |
Significant association: *p ≤ 0.05
aWithin-sib-pairs association estimate model adjusted for three covariates (age, sex and location); all values are represented as β (95% CI), where β = coefficient from the linear regression on log-transformed z scores
bCorrected overall critical p value using false-discovery rate for each trait = 0.002
cMajor allele of locus THADA (for rest of the loci minor allele was taken as reference)
dAlso known as C4ORF32