Table 2.

Cognitive testing by Kt/V

Cognitive test	Function tested	Univariate		Parsimonious		Multivariable
		β-coefficient	p value	β-coefficient	p value	β-coefficient	p value
MMSE	screen	−0.45	0.010	−0.57	0.001	−0.48	0.012
NAART	intelligence	0.04	0.958	−0.57	0.413	−0.95	0.220
Percent retention	primary cortical (memory)	−1.12	0.519	−2.69	0.126	−1.32	0.510
Recognition		−0.29	0.116	−0.47	0.007	−0.46	0.024
Block design	primary subcortical	−0.56	0.396	−0.59	0.327	−0.13	0.843
Digit symbol coding	(executive function and	0.72	0.524	−0.68	0.462	−0.61	0.546
Trails A	processing speed)	0.37	0.876	1.68	0.472	0.60	0.820
Trails B		1.28	0.857	7.12	0.255	1.50	0.823

Results represent per 1 SD (0.24) increase in Kt/V. Trails B analyses were performed using Tobit regression to account for failure to complete the task within 5 min. Negative β-coefficients indicate worse performance associated with high Kt/V for all tests except Trials A and B where a positive score indicates worse performance. Parsimonious models adjust for age, sex, race and education while full multivariable models additionally adjust primary cause of ESRD, dialysis vintage, BMI, history of smoking, history of cardiovascular disease, hematocrit and albumin. NAART = North American Adult Reading Test.