Table 3.
Results of multivariate analysis for transplant-related mortality
| N1/N2 | Hazard Ratio 95% CI |
P- value |
|
|---|---|---|---|
| Mismatch at HLA-C vs. match at HLA-C* | |||
| Zero mismatch at HLA-A, -B, -DRB1 | 6/23 vs. 6/69 | 3.97 (1.27 – 12.40) | 0.018 |
| 1-locus mismatch at HLA-A or –B or –DRB1 | 66/234 vs. 23/127 | 1.70 (1.06 – 2.74) | 0.029 |
| 2-loci mismatch at HLA-A and/or –B and/or –DRB1 | 101/293 vs. 17/57 | 1.25 (0.74 – 2.09) | 0.404 |
| Mismatch at HLA-A vs. match at HLA-A* | |||
| Zero mismatch at HLA-B, -C, -DRB1 | 10/62 vs. 6/69 | 1.94 (0.70 – 5.35) | 0.201 |
| 1-locus mismatch at HLA-B, or –C or DRB1 | 21/78 vs. 18/88 | 1.11 (0.59 – 2.10) | 0.743 |
| 2-loci mismatch at HLA-B and/or –C and/or –DRB1 | 47/140 vs. 53/181 | 1.07 (0.72 – 1.58) | 0.752 |
| ≥3-loci mismatch at HLA-B and/or –C and/or –DRB1 | 15/34 vs. 49/151 | 1.36 (0.76 – 2.43) | 0.307 |
| Mismatch at HLA-B vs. match at HLA-B* | |||
| Zero mismatch at HLA-A, -C, -DRB1 | 4/24 vs. 6/69 | 2.66 (0.74 – 9.50) | 0.133 |
| 1-locus mismatch at HLA-A, or –C or DRB1 | 40/153 vs. 23/125 | 1.57 (0.93 – 2.63) | 0.088 |
| 2-loci mismatch at HLA-A and/or –C and/or –DRB1 | 61/193 vs. 39/112 | 0.90 (0.60 – 1.35) | 0.613 |
| ≥3-loci mismatch at HLA-A and/or –C and/or –DRB1 | 20/57 vs. 26/70 | 0.80 (0.44 – 1.43) | 0.444 |
| Mismatch at HLA-DRB1 vs. match at HLA-DRB1* | |||
| Zero mismatch at HLA-A, -B, -C | 10/51 vs. 6/69 | 1.95 (0.71 – 5.28) | 0.198 |
| 1-locus mismatch at HLA-A or –B or -C | 33/77 vs. 17/101 | 2.63 (1.46 – 4.74) | 0.001 |
| 2-loci mismatch at HLA-A and/or –B and/or –C | 40/119 vs. 44/181 | 1.26 (0.82 – 1.94) | 0.288 |
| ≥3-loci mismatch at HLA-A and/or –B and/or –C | 13/37 vs. 56/168 | 1.03 (0.56 – 1.88) | 0.931 |
| Zero, single or multiple loci mismatches | |||
| HLA-A, -B, -C, -DRB1 match§ ◊ | 6/69 | 1.00 | |
| 1-locus HLA-A, -B, -C, -DRB1 mismatch | 27/147 | 2.02 (0.83 – 4.91) | 0.12 |
| 2-loci HLA-A, -B, -C, -DRB1 mismatch | 75/259 | 3.27 (1.42 – 7.54) | 0.006 |
| 3-loci HLA-A, -B, -C, -DRB1 mismatch | 83/253 | 3.34 (1.45 – 7.71) | 0.005 |
| 4-loci HLA-A, -B, -C, -DRB1 mismatch | 28/75 | 3.51 (1.44 – 8.58) | 0.006 |
N1=number of events; N2=number evaluable
The relative hazards ratio of transplant-related mortality associated with a single HLA-A mismatch, HLA-B mismatch, HLA-C mismatch or HLA-DRB1 mismatch versus a match at that locus (HR 1.00) in the presence of 0, 1, 2, ≥3 mismatches at other loci. Matching at HLA-C was examined in the presence of 0, 1 or 2 mismatches.
The relative hazard ratio considering 1, 2, 3 or 4 mismatches at any loci vs.0 mismatch
Pair-wise test
2-loci mismatch vs. 1-locus mismatch: HR 1.62, 95% CI 1.04 – 2.52, p=0.032
3-loci mismatch vs. 1-locus mismatch: HR 1.65, 95% CI 1.07 – 2.57, p=0.024
4-loci mismatch vs. 1-locus mismatch: HR 1.74, 95% CI 1.02 – 2.97, p=0.042
3-loci mismatch vs. 2-loci mismatch: HR 1.02, 95% CI 0.75 – 1.40, p=0.884
4-loci mismatch vs. 2-loci mismatch: HR 1.07, 95% CI 0.69 – 1.67, p=0.748
4-loci mismatch vs. 3-loci mismatch: HR 1.05, 95% CI 0.68 – 1.62, p=0.826