Table 4.
Results of multivariate analysis for overall mortality
| N1/N2 | Hazard Ratio 95% CI |
P-value | |
|---|---|---|---|
| Mismatch at HLA-C vs. match at HLA-C* | |||
| Zero mismatch at HLA-A, -B, -DRB1 | 10/23 vs. 29/69 | 1.22 (0.63 – 2.34) | 0.559 |
| 1-locus mismatch at HLA-A or –B or –DRB1 | 130/234 vs. 57/127 | 1.42 (1.05 – 1.91) | 0.023 |
| 2-loci mismatch at HLA-A and/or –B and/or –DRB1 | 163/293 vs. 29/57 | 1.17 (0.80 – 1.72) | 0.424 |
| Mismatch at HLA-A vs. match at HLA-A* | |||
| Zero mismatch at HLA-B, -C, -DRB1 | 10/62 vs. 6/69 | 0.99 (0.60 – 1.54) | 0.863 |
| 1-locus mismatch at HLA-B, or –C or DRB1 | 21/78 vs. 18/88 | 1.29 (0.85 – 1.95) | 0.233 |
| 2-loci mismatch at HLA-B and/or –C and/or –DRB1 | 47/140 vs. 53/181 | 0.92 (0.69 – 1.23) | 0.568 |
| ≥3-loci mismatch at HLA-B and/or –C and/or –DRB1 | 15/34 vs. 49/151 | 1.03 (0.64 – 1.65) | 0.919 |
| Mismatch at HLA-B vs. match at HLA-B* | |||
| Zero mismatch at HLA-A, -C, -DRB1 | 4/24 vs. 6/69 | 1.42 (0.70 – 2.86) | 0.331 |
| 1-locus mismatch at HLA-A, or –C or DRB1 | 40/153 vs. 23/125 | 1.29 (0.91 – 1.83) | 0.147 |
| 2-loci mismatch at HLA-A and/or –C and/or –DRB1 | 61/193 vs. 39/112 | 0.90 (0.66 – 1.24) | 0.526 |
| ≥3-loci mismatch at HLA-A and/or –C and/or –DRB1 | 20/57 vs. 26/70 | 0.78 (0.49 – 1.23) | 0.278 |
| Mismatch at HLA-DRB1 vs. match at HLA-DRB1* | |||
| Zero mismatch at HLA-A, -B, -C | 22/51 vs. 29/69 | 0.66 (0.39 – 1.11) | 0.119 |
| 1-locus mismatch at HLA-A or –B or -C | 45/77 vs. 44/101 | 1.36 (0.91 – 2.11) | 0.129 |
| 2-loci mismatch at HLA-A and/or –B and/or –C | 67/119 vs. 98/181 | 0.91 (0.67 – 1.24) | 0.560 |
| ≥3-loci mismatch at HLA-A and/or –B and/or –C | 23/37 vs. 90/168 | 1.10 (0.70 – 1.73) | 0.675 |
| Zero, single or multiple loci mismatches | |||
| HLA-A, -B, -C, -DRB1 match§ ◊ | 29/69 | 1.00 | |
| 1-locus HLA-A, -B, -C, -DRB1 mismatch | 65/147 | 1.06 (0.68 – 1.65) | 0.801 |
| 2-loci HLA-A, -B, -C, -DRB1 mismatch | 142/259 | 1.38 (0.92 – 2.07) | 0.118 |
| 3-loci HLA-A, -B, -C, -DRB1 mismatch | 136/253 | 1.33 (0.88 – 2.01) | 0.171 |
| 4-loci HLA-A, -B, -C, -DRB1 mismatch | 46/75 | 1.33 (0.83 – 2.15) | 0.242 |
N1=number of events; N2=number evaluable
The relative hazards ratio of overall mortality associated with a single HLA-A mismatch, HLA-B mismatch, HLA-C mismatch or HLA-DRB1 mismatch versus a match at that locus (HR 1.00) in the presence of 0, 1, 2, ≥3 mismatches at other loci. Matching at HLA-C was examined in the presence of 0, 1 or 2 mismatches.
The relative hazard ratio considering 1, 2, 3 or 4 mismatches at any loci vs. 0 mismatch
Pair-wise test
2-loci mismatch vs. 1-locus mismatch: HR 1.30, 95% CI 0.97 – 1.75, p=0.078
3-loci mismatch vs. 1-locus mismatch: HR 1.26, 95% CI 0.93 – 1.69, p=0.133
4-loci mismatch vs. 1-locus mismatch: HR 1.26, 95% CI 0.86 – 1.84, p=0.243
3-loci mismatch vs. 2-loci mismatch: HR 0.96, 95% CI 0.76 – 1.22, p=0.759
4-loci mismatch vs. 2-loci mismatch: HR 0.96, 95% CI 0.69 – 1.35, p=0.827
4-loci mismatch vs. 3-loci mismatch: HR 1.01, 95% CI 0.77 – 1.40, p=0.998