Table 5.
Results of multivariate analysis for neutrophil recovery
| N1/N2 | Odds Ratio 95% CI |
P- value |
|
|---|---|---|---|
| Mismatch at HLA-C vs. match at HLA-C* | |||
| Zero mismatch at HLA-A, -B, -DRB1 | 19/23 vs. 63/69 | 1.01 (0.34 – 2.98) | 0.982 |
| 1-locus mismatch at HLA-A or –B or –DRB1 | 208/234 vs. 117/127 | 1.10 (0.69 – 1.74) | 0.692 |
| 2-loci mismatch at HLA-A and/or –B and/or –DRB1 | 248/293 vs. 46/57 | 0.75 (0.42 – 1.36) | 0.344 |
| Mismatch at HLA-A vs. match at HLA-A* | |||
| Zero mismatch at HLA-B, -C, -DRB1 | 58/62 vs. 63/69 | 0.63 (0.30 – 1.34) | 0.231 |
| 1-locus mismatch at HLA-B, or –C or DRB1 | 66/78 vs. 78/88 | 0.76 (0.40 – 1.44) | 0.396 |
| 2-loci mismatch at HLA-B and/or –C and/or –DRB1 | 123/140 vs. 158/181 | 0.63 (0.40 – 1.01) | 0.056 |
| ≥3-loci mismatch at HLA-B and/or –C and/or –DRB1 | 26/34 vs. 129/151 | 0.37 (0.17 – 0.82) | 0.014 |
| Mismatch at HLA-B vs. match at HLA-B* | |||
| Zero mismatch at HLA-A, -C, -DRB1 | 21/24 vs. 63/69 | 0.89 (0.32 – 2.51) | 0.828 |
| 1-locus mismatch at HLA-A, or –C or DRB1 | 137/153 vs. 114/125 | 1.60 (0.95 – 2.70) | 0.078 |
| 2-loci mismatch at HLA-A and/or –C and/or –DRB1 | 170/193 vs. 92/112 | 0.87 (0.54 – 1.40) | 0.559 |
| ≥3-loci mismatch at HLA-A and/or –C and/or –DRB1 | 46/57 vs. 58/70 | 0.93 (0.46 – 1.88) | 0.837 |
| Mismatch at HLA-DRB1 vs. match at HLA-DRB1* | |||
| Zero mismatch at HLA-A, -B, -C | 45/51 vs. 63/69 | 0.71 (0.32 – 1.57) | 0.402 |
| 1-locus mismatch at HLA-A or –B or -C | 63/77 vs. 93/101 | 0.62 (0.33 – 1.15) | 0.129 |
| 2-loci mismatch at HLA-A and/or –B and/or –C | 100/119 vs. 159/181 | 0.57 (0.35 – 0.93) | 0.024 |
| ≥3-loci mismatch at HLA-A and/or –B and/or –C | 30/37 vs. 148/168 | 1.54 (0.74 – 3.23) | 0.250 |
| Zero, single or multiple loci mismatches | |||
| HLA-A, -B, -C, -DRB1 match§ | 63/69 | 1.00 | |
| 1-locus HLA-A, -B, -C, -DRB1 mismatch | 134/147 | 0.73 (0.39 – 1.38) | 0.37 |
| 2-loci HLA-A, -B, -C, -DRB1 mismatch | 223/259 | 0.80 (0.44 – 1.45) | 0.46 |
| 3-loci HLA-A, -B, -C, -DRB1 mismatch | 222/253 | 0.54 (0.30 – 0.98) | 0.004 |
| 4-loci HLA-A, -B, -C, -DRB1 mismatch | 59/75 | 0.32 (0.16 – 0.65) | 0.002 |
N1=number of events; N2=number evaluable
*
The relative odds ratio of neutrophil recovery associated with a single HLA-A mismatch, HLA-B mismatch, HLA-C mismatch or HLA-DRB1 mismatch versus a match at that locus (OR 1.00) in the presence of 0, 1, 2, ≥3 at other loci. Matching at HLA-C was examined in the presence of 0, 1 or 2 mismatches.
§
The relative odds ratio considering 1, 2, 3 or 4 mismatches at any loci vs.0 mismatch