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. Author manuscript; available in PMC: 2012 Dec 21.
Published in final edited form as: Bioconjug Chem. 2011 Nov 18;22(12):2593–2599. doi: 10.1021/bc2004457

Figure 2.

Figure 2

δF508-CFTR corrector activity and cellular uptake of 5. (A) Short-circuit measurements showing apical membrane chloride current after incubation for 24 h at 37 °C with 10 µM of indicated fluorescent bithiazoles. Negative control was incubation with DMSO vehicle alone and positive control was incubation with corr-4a (5 µM). Forskolin (20 µM), genistein (50 µM) and CFTRinh-172 (10 µM) were added as indicated. (B) Confocal micrographs of live FRT cells after incubation with 5 for 1 or 15 min; for comparison, ER staining shown of FRT cells expressing an ER-targeted GFP. Scale bar, 5 µm.