TABLE 2.
Prevalence of extraintestinal manifestations of inflammatory bowel disease
| Extraintestinal manifestation | Prevalence in adults with IBD
|
|
|---|---|---|
| UC EIM (%) | CD EIM (%) | |
| Dermatology (2,7) | 3.8–19 | 10.2–23 |
| Erythema nodosum (2,7,13–15,84) | 0.9–4 | 0.7–15 |
| Pyoderma gangrenosum (2,7) | 0.5–5 | 0.8–1.6 |
| Epidermolysis bullosa (85,86) | CR | |
| Sweet syndrome (21,87) | CR | |
| Uveitis/iritis (2,7) | 1.5–4 | 2–13 |
| Joints/arthritis (2,7) | 10.2–26 | 22.4–39 |
| Ankylosing spondylitis (2,7) | 1.5–9 | 2.7–17 |
| Osteoporosis and osteopenia (7) | 9 | 17 |
| PSC (1,2) | 3–12.4 | 0.4–22.4 |
| NAFLD/NASH (2) | 9.4 | 19.3 |
| Nephrolithiasis (7) | 5 | 5 |
| Amyloidosis (67) | 0.7 | 0.9 |
| Pancreatitis (7) | 0.2–0.5 | 0.4 |
| Anemia (2) | 17.7 | 9.6 |
| Vascular thrombosis (2) | 1.8 | |
| Oral aphthous ulcers (2,7) | 0.5–4 | 11 |
|
| ||
| Extraintestinal manifestation | Prevalence in children with IBD
|
|
| UC EIM (%) | CD EIM (%) | |
|
| ||
| Pyoderma gangrenosum (88) | CR* | |
| Joints/arthritis (6) | 3.8 | – |
| Osteoporosis and osteopenia (6,39) | 24–25 | 8–41 |
| Growth delay (6) | 28 | 81 |
| Nephrolithiasis (6,89) | 3.2 | CR |
| Autoimmune hepatitis (6) | 1.3 | – |
| Uveitis (6) | 0.63 | – |
| Amyloidosis (90) | CR | |
| Vascular damage (6) | 0.63 | 4.2 |
| Pancreatitis (6) | 2.5 | 3.9 |
| Anemia (6) | 40.5 | 69 |
*
Except where noted by “CR” (case report) CD total N in children ranges from 21 to 26 and UC total N ranges from 21 to 158.