Fig. 2.
Current–voltage (I–V) relationship for WT and L532P IhERG. (A, B) Upper panels show representative families of currents from WT hERG (A) and L532P hERG (B), elicited by the voltage protocol shown in the lower panel (start-to-start interval of 12 s between successive voltage steps). For clarity only selected sweeps are shown; note that the current scales in A and B differ. (C) Mean I–V relations for end-pulse current (n = 7 for WT and n = 9 for L532P). (D) Mean normalized tail current I–V relations; for each of WT (n = 7) and L532P (n = 9) data were normalized to the maximal current recorded during the protocol. (* denotes statistic significance of P < 0.05, ** of P ≤ 0.01, *** of P ≤ 0.005, **** of P ≤ 0.001).