Table 1.
Comparison of biophysical parameters for WT and L532P hERG.
| Property | WT | L532P |
|---|---|---|
| Vact 0.5(mV) | − 16.6 ± 2.3 | 19.2 ± 2.8 |
| k (activation, mV) | 6.8 ± 0.3 | 12.4 ± 0.9 |
| (n = 7 for both) | (n = 9 for both) | |
| τact (ms) | 67.9 ± 6.1 | 32.6 ± 2.2 |
| (n = 9) | (n = 6) | |
| Erev (mV) | − 84.3 ± 0.9 | − 80.3 ± 0.8 |
| (n = 6) | (n = 9) | |
| Vinact0.5(mV) | − 70.3 ± 1.7 | − 38.7 ± 3.7 |
| k (inactivation,mV) | 19.6 ± 0.5 | 28.7 ± 2.8 |
| (n = 9 for both) | (n = 6 for both) | |
| τinact (ms) | 1.34 ± 0.13 | 1.0 ± 0.06 |
| (n = 9) | (n = 6) | |
| τrec (ms) | 1.92 ± 0.07 | 1.43 ± 0.12 |
| (n = 10) | (n = 11) |
Abbreviations: Vact 0.5, half-maximal activation voltage; τact, time constant of activation; Erev, reversal potential; Vinact0.5, half-maximal inactivation voltage; k, slope factor for activation or inactivation relationship; τinact, time constant of inactivation; τrec, time constant of recovery from inactivation; n = number of experimental replicates. Data are presented as mean ± s.e. mean.