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. 2011 Sep 10;40(1):75–87. doi: 10.1093/nar/gkr614

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© The Author(s) 2011. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — SET/TAF-Iβ represses p53-mediated cell cycle arrest and apoptosis and induces proliferation. (A) Doxorubicin-treated H1299 cells were transfected with the indicated constructs for MTT assay. Results are shown as means ± SD; n = 3. **P < 0.01 and ***P < 0.001 compared with Day 0. (B) HCT116 cells were transfected with p53, SET/TAF-Iβ, sh-CTL and sh-SET/TAF-Iβ #1 or #2 as indicated upon doxorubicin treatment. At 72-h post-transfection, cells were fixed and BrdU assays performed. Results are shown as means ± SD. n = 3. **P < 0.01 and ***P < 0.001. (C) FACS analysis of H1299 cells transfected with p53 alone or co-transfected with SET/TAF-Iβ, SET/TAF-IβΔ3, sh-CTL and sh-SET/TAF-Iβ #1 or #2, followed by doxorubicin treatment. (D) H1299 cells transiently transfected with the indicated constructs upon doxorubicin treatment were subjected to TUNEL assay. DNase I-treated cells were shown as a positive control. The numbers of TUNEL-positive cells are shown in the numbers below the pictures.