Figure 1.

Structures of zidovudine (ZDV), 3′-azido-2′,3′-dideoxyadenosine (3′-azido-ddA), 3′-azido-2′,3′-dideoxyguanosine (3′-azido-ddG), 3′-azido-2′,3′-dideoxy-2,6-diaminopurine (3′-azido-2,6-DA-P), 3′-azido-2′,3′-dideoxy-2-amino-6-chloropurine (3′-azido-6-Cl-P), 3′-azido-2′,3′-dideoxy-2-amino-6-N,N-dimethylaminopurine (3′-azido-6-DM-P), 3′-azido-2′,3′-dideoxy-2-amino-6-methoxypurine (3′-azido-6-MX-P) and 3′-azido-2′,3′-dideoxy-2-amino-6-N-allylaminopurine (3′-azido-6-AA-P). The EC₅₀ values, adapted from Zhang et al. (5), are for WT HIV-1 and were determined in peripheral blood mononuclear (PBM) cells.