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. 2011 Sep 13;40(1):381–390. doi: 10.1093/nar/gkr756

Figure 2.

Figure 2.

6-Modified-3′-azido-ddGTPs are recognized and incorporated by WT HIV-1 as adenosine analogs. (A) Representative denaturing polyacrylamide gel showing chain-termination of HIV-1 RT DNA synthesis by each of the 3′-azido-ddGTPs on a heteropolymeric DNA/DNA T/P under steady-state assay conditions. (B) Representative denaturing polyacrylamide gel showing chain termination of WT HIV-1 RT DNA synthesis by each of the 3′-azido-ddGTPs on a heteropolymeric RNA/DNA T/P under steady-state assay conditions. Reaction conditions are described in the ‘Materials and Methods’ section.