Table 5.

Adjusted Pearson Correlation Coefficients for Cytokines and Cytokine Modulators^a

	CRP	IL-1β	IL-2	IL-4	IL-5	IL-6	IL-10	IL-12 p70	IL-13	TNFα	IL-1RA	sIL-1R ll	sIL-2Ra	sIL-4R	sIL-6R	IL-12 p40	sTNF-R1
IL-1β	0.02
IL-2	0.03	0.77***
IL-4	0.06	0.20***	0.22***
IL-5	0.01	0.22***	0.21***	0.58***
IL-6	0.12*	0.29***	0.28***	0.84***	0.62***
IL-10	0.07	0.36***	0.32***	0.11*	0.37***	0.21***
IL-12 p70	−0.02	0.49***	0.45***	0.14**	0.35***	0.35***	0.66***
IL-13	0.00	0.31***	0.27***	0.65***	0.43***	0.68***	0.36***	0.41***
TNFα	0.07	0.30***	0.23***	0.12*	0.19***	0.21***	0.34***	0.34***	0.19***
IL-1RA	0.03	0.35***	0.36***	0.05	0.04	0.04	0.06	0.11*	0.06	−0.03
sIL-1Rll	0.12	−0.02	−0.01	0.07	0.10	0.05	0.07	0.01	0.04	0.12	−0.06
sIL-2Ra	0.19**	0.03	0.02	0.06	0.05	0.04	0.11	−0.03	−0.01	0.15*	0.00	0.41***
sIL-4R	−0.05	0.18**	0.21***	0.13*	0.13*	0.18**	0.09	0.25***	0.11	0.09	0.09	0.20***	0.33***
sIL-6R	0.05	−0.02	−0.04	−0.01	−0.03	−0.01	−0.08	−0.10	−0.01	0.07	−0.15*	0.01	−0.01	−0.08
IL-12p40	0.04	0.29***	0.26***	0.08	0.07	0.04	0.18***	0.12*	0.11*	0.14**	0.56***	−0.04	0.18**	0.05	−0.10
sTNF-R1	0.10	0.19***	0.16***	0.01	0.01	0.03	0.09	0.03	0.02	0.11*	0.46***	0.00	0.25***	0.10	−0.08	0.57***
sTNF-R2	0.10	−0.06	−0.08	−0.07	0.02	−0.05	0.02	−0.07	−0.06	0.11*	−0.05	0.04	0.16**	−0.10	0.14*	0.08	0.18***

Note: CRP: C-reactive protein, IL: interleukin, RA: receptor antagonist, Ra: receptor alpha, R: receptor, TNF: tumor necrosis factor. Cytokines and cytokine modulators were log transformed.

Coefficients with * are significant at P< 0.01, with ** at P<0.001, and with *** at P<0.0001.

Correlations are based on a different number of subjects for each pair of markers, ranging from 390 to 616 subjects.

^aAll models adjusted for study (NYUWHS-OVCA, NYUWHS-NHL, ORDET, NSHDS), age at blood sampling, and body mass index.