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. Author manuscript; available in PMC: 2012 Dec 16.
Published in final edited form as: ACS Chem Biol. 2011 Nov 14;6(12):1321–1326. doi: 10.1021/cb200308e

Figure 1.

Figure 1

(a) The transcriptional activation domain (TAD) of amphipathic activators can engage in high affinity interactions, such as those with masking proteins (mp), but the interactions between the TAD and coactivator complexes are more moderate in affinity and transient in nature (16–21). (b) Amphipathic activators share little sequence homology but do share binding targets, at least in vitro. The photocrosslinking amino acid, Bpa, has been incorporated within the Gal4 TAD (positions of incorporation in red) with little impact on the function and binding profile of that TAD (22).