Table 1.
Characteristics of the patients
| Variable | AO (n =36) | AOA (n =41) | P value |
|---|---|---|---|
| Age | |||
| median | 39 | 45 | .113 |
| Gender | |||
| Male | 22 | 25 | |
| Female | 14 | 16 | .961 |
| Preoperative KPS score | |||
| ≥80 | 31 | 32 | |
| <80 | 5 | 9 | .755 |
| LOH 1p | |||
| Yes | 19 | 20 | |
| No | 17 | 21 | .570 |
| LOH 19q | |||
| Yes | 25 | 21 | |
| No | 11 | 20 | .393 |
| LOH 1p or 19q | |||
| Yes | 28 | 27 | |
| No | 8 | 14 | .665 |
| LOH 1p and 19q | |||
| Yes | 14 | 14 | |
| No | 22 | 27 | .615 |
| MGMT promoter gene | |||
| Methylated | 19 | 19 | |
| Unmethylated | 17 | 22 | .726 |
| IDH1 | |||
| Not mutated | 9 | 13 | |
| Mutated | 14 | 11 | .385 |
| MGMT expression | |||
| Low | 16 | 20 | |
| High | 20 | 21 | .529 |
| EGFR expression | |||
| Low | 26 | 20 | |
| High | 10 | 21 | .225 |
| P53 expression | |||
| Low | 11 | 11 | |
| High | 25 | 30 | .593 |
| Ki-67 expression | |||
| Low | 21 | 28 | |
| High | 15 | 13 | .395 |
| Reoperation after progression | |||
| Yes | 6 | 8 | |
| No | 30 | 33 | .879 |
| Extent of resection | |||
| Total | 14 | 14 | |
| Subtotal | 22 | 27 | .880 |
| Adjuvant chemotherapy | |||
| Yes | 23 | 28 | |
| No | 13 | 13 | .244 |
| Mean OS time (months) | 40.6 | 30.8 | .44 |
Abbreviations: AO, anaplastic oligodendroglioma; AOA, anaplastic oligoastrocytoma; KPS, Karnofsky performance status; LOH, loss of heterozygosity; OS, overall survival.