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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2012 Jan;71(1):73–82. doi: 10.1097/NEN.0b013e318240fa65

Figure 1.

Figure 1

Survival according to 1p/19q fluorescence in situ hybridization (FISH) and loss of heterozygosity (LOH) analyses. (A) Grade III oligodendrogliomas had worse survival than grade II tumors (*p < 0.0001). (B, C) 1p/19q FISH (B) was weaker than PCR-based LOH (C) in differentiating longer-term from shorter-term survivors. This difference was most prominent in grade III anaplastic oligodendroglial tumors, in which prognostic stratification was better by LOH (**p < 0.0001) than by FISH (*p = 0.02). FISH could not stratify grade II oligodendrogliomas (p = 0.64), survival differences trended toward significance by LOH (p = 0.09). (D) Grade II oligodendrogliomas with 1p/19q codeletion by both modalities had longer survival than those that were positive by FISH but not by LOH (*p = 0.04; p = 0.26 vs. tumors that were negative by both tests). (E) Grade III anaplastic oligodendrogliomas that were codeleted by FISH and LOH showed longer survival compared to tumors that were negative by both tests (*p = 0.0006), or positive only by FISH but not LOH (*p < 0.0001). (F) Increasing the stringency of FISH codeletion criteria to a cutoff 1p36/1q25 and 19q13/19p13 ratio of 0.75 for each probe pair (from the original cutoff of 0.87) improved statistical power in stratifying grade III anaplastic oligodendrogliomas (*p = 0.007).