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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2012 Jan;71(1):73–82. doi: 10.1097/NEN.0b013e318240fa65

Figure 3.

Figure 3

Impact of 10q loss of heterozygosity (LOH) on survival in oligodendrogliomas. (A, B) 10q LOH did not significantly change overall survival in grade II gliomas (A, p = 0.12) though it did in grade III gliomas (B, *p = 0.002). (C, D) Factoring in 1p/19q status, 10q LOH still did not significantly alter survival in grade II oligodendrogliomas as assessed by 1p/19q FISH (C, p = 0.39) or PCR-based LOH (D, p = 0.27), although the number of cases with 1p/19q codeletion and 10q LOH was very small (n = 3). (E) In grade III oligodendrogliomas, 1p/19q-codeleted cases by fluorescence in situ hybridization (FISH) had better survival only if 10q was also intact (*p = 0.03 vs. all other groups). (F) 10q status did not significantly refine survival when grade III oligodendrogliomas were 1p/19q-codeleted via PCR-based LOH (p = 0.86). Survival of 1p/19q-intact grade III oligodendrogliomas was slightly but significantly longer when 10q was also intact (*p = 0.03 for 1p/19q LOH-negative (neg.) 10q-intact vs. 1p/19q LOH-neg 10q LOH).