. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: J Neuropathol Exp Neurol. 2012 Jan;71(1):73–82. doi: 10.1097/NEN.0b013e318240fa65

Table 5.

Multivariate Analysis of Overall Survival Based on Age and Molecular Variables in Grade III Oligodendrogliomas

variable	original 1p/19q FISH criteria		modified 1p/19q FISH criteria		1p/19q PCR LOH
variable	Relative Risk (95% CI)	p	Relative Risk (95% CI)	p	Relative Risk (95% CI)	p
age <45 years	0.07 (0.01—0.51)	0.009	0.06 (0.008—0.5)	0.009	0.12 (0.02—0.9)	0.04
10q intact	0.27 (0.08—0.85)	0.025	0.28 (0.09—0.9)	0.03	0.36 (0.1—1.3)	0.12
no polysomy	0.70 (0.19—2.5)	0.58	0.61 (0.16—2.3)	0.46	0.72 (0.2—2.2)	0.56
EGFR IHC moderate-to-strong	0.27 (0.08—0.88)	0.03	0.27 (0.08—0.9)	0.03	0.42 (0.12—1.4)	0.17
1p/19q deleted	0.72 (0.17—3.0)	0.65	0.53 (0.16—1.8)	0.31	0.30 (0.05—1.7)	0.18

Analysis of 26 grade III anaplastic oligodendrogliomas showed that younger patient age, intact 10q, and moderate-to-strong EGFR expression on IHC were independent favorable prognostic variables for overall survival when incorporating either original or modified 1p/19q FISH criteria. When using 1p/19q PCR-based LOH data instead, the only variable that retained significance was patient age. CI = confidence interval; EGFR = epidermal growth factor; FISH = fluorescence in situ hybridization; IHC = immunohistochemistry. LOH = loss of heterozygosity.