Figure 7. Natural helper cells and NKT cells are required for α-GalCer induced AHR.
(A) Schematic showing the protocol for adoptive transfer of natural helper cells or NKT cells. Change in lung resistance (B) and inflammatory cells in BAL fluid (C) in IL-13−/− recipients (n = 4 per group) given purified natural helper cells (Lin−ST2+ subsets) from WT donors followed by vehicle or α-GalCer challenge for 24 hr. Mac, macrophage; Neu, neutrophils; Eos, eosinophils; Lymph, lymphocytes.
Change in lung resistance (D) and inflammatory cells in BAL fluid (E) in IL-13−/− recipients (n = 4 per group) given purified NKT cells from WT donors followed by vehicle or α-GalCer challenge for 24 hr. Mac, macrophage; Neu, neutrophils; Eos, eosinophils; Lymph, lymphocytes.