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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 26;880C:132–139. doi: 10.1016/j.jchromb.2011.11.029

Figure 1. Formation of MPB-Derivatized Clopidogrel Active Metabolite.

Figure 1

Clopidogrel is oxidized to the inactive intermediate 2-oxo-clopidogrel, before subsequent further oxidation to the free thiol-containing active metabolite. Due to its reactivity, the active metabolite is added to 2-bromo-3’-methoxyphenone (MPB) to derivatize the thiol to provide stability for more accurate quantification.