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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 26;880C:132–139. doi: 10.1016/j.jchromb.2011.11.029

Figure 2. Chromatogram of A) blank plasma extract, B) mid quality control sample, and C) clinical sample.

Figure 2

Figure 2

Figure 2

Panel A represents a blank plasma extract, Panel B represents a mid quality control sample (MQC), and Panel C represents a clinical sample. There are three separate LC-MS/MS chromatographic tracings within each panel resulting from three simultaneous multiple reaction monitoring (MRM) transitions. The bottom pane represents the internal standard ticlopidine (m/z 264>154); the middle pane represents CAMD (m/z 504>155); and the top pane represents clopidogrel (m/z 322>212). The racemic CAMD reference standard produces a broad peak (B), due to the presence of both stereoisomers. Clinical samples demonstrate the stereoselective metabolism, preferentially forming one stereoisomer as evident by the relatively sharper peak shape.