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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2011 Oct 29;52(1):283–291. doi: 10.1016/j.yjmcc.2011.10.016

Figure 6. Proposed scheme of Epac activated hypertrophic signaling in cardiac myocytes.

Figure 6

Epac leads to PLC activation and IP3 production. Activation of IP3Rs induces Ca2+ leak from stores, which 1) sensitizes RyRs, 2) activates CaMKII and 3) induces increase in intranuclear Ca2+. The increase in [Ca2+]n and CaMKII activation translocates HDAC out of the nucleus releasing the repression against hypertrophy development.