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. Author manuscript; available in PMC: 2012 Dec 23.
Published in final edited form as: Chem Biol. 2011 Dec 23;18(12):1521–1526. doi: 10.1016/j.chembiol.2011.10.012

Figure 4. Crystal structures of human α-GAL bound to pharmacological chaperones.

Figure 4

(a) and (b) show σA-weighted 2Fo-Fc electron density maps of DGJ- and galactose-soaked crystals of wild-type human α-GAL, and (c) shows the D170A mutant α-GAL with DGJ bound. All maps are contoured at 1.8σ with the ligand density colored red for clarity. (d) shows a superposition of the (a) and (b), highlighting the key interaction between the ligand and the D170 carboxylate. See also Table S3.

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